In vivo oncolytic activity of non-virulent newcastle disease virus Iraqi strain against mouse mammary adenocarcinoma

Newcastle disease virus (NDV) is promising antitumor agent that triggers immediate cytolysis of the tumor, apoptosis and activation immune system. This study was aimed at testing antiangiogenic NDV Performance on a model breast cancer. has been studied against mammalian adenocarcinoma AN3 transplanted into syngeneic immunocompetent mice through intratumoral injection to determine activity in vivo. Histopathological sections for treated tumor mass demonstrated proliferation granulation tissue with substantial necrosis region. indicated role Iraqi strain reducing volume solid when compared untreated group which confirmed feature make as anti-tumor agents.